Detalhe da pesquisa
1.
Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development.
J Infect Dis
; 228(Suppl 5): S337-S354, 2023 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37669225
2.
Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit.
J Infect Dis
; 224(Supplement_1): S1-S21, 2021 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34111271
3.
Optimization of ether and aniline based inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett
; 41: 127974, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33771585
4.
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.
Nature
; 522(7555): 216-20, 2015 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25896324
5.
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Mol Pharmacol
; 96(5): 629-640, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31515284
6.
High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.
J Biol Chem
; 293(35): 13750-13765, 2018 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29945974
7.
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
Nat Chem Biol
; 12(6): 452-8, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27110680
8.
Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.
Bioorg Med Chem
; 26(8): 1727-1739, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29555419
9.
A high-content imaging-based screening pipeline for the systematic identification of anti-progeroid compounds.
Methods
; 96: 46-58, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26341717
10.
Correction: Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin.
J Biol Chem
; 295(13): 4370, 2020 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32221035
11.
Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin.
J Biol Chem
; 289(31): 21473-89, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24930045
12.
Structure activity relationships of human galactokinase inhibitors.
Bioorg Med Chem Lett
; 25(3): 721-7, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25553891
13.
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat Chem Biol
; 8(10): 839-47, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22922757
14.
Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.
Bioorg Med Chem Lett
; 24(2): 630-5, 2014 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24360556
15.
Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET.
Proc Natl Acad Sci U S A
; 108(6): 2593-8, 2011 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-21262843
16.
Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
Nat Chem Biol
; 12(8): 656, 2016 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27434767
17.
2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Bioorg Med Chem Lett
; 21(21): 6322-7, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21958545
18.
Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.
J Med Chem
; 64(8): 4913-4946, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33822623
19.
N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier.
Drug Metab Dispos
; 38(6): 917-22, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20212014
20.
Muscleblind-like 1 is a negative regulator of TGF-beta-dependent epithelial-mesenchymal transition of atrioventricular canal endocardial cells.
Dev Dyn
; 238(12): 3266-72, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19890912